Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/9465
Título: Treatment of Cognitive Deficits in Alzheimer's disease: A psychopharmacological review
Autor: Campos, Carlos
Rocha, Nuno Barbosa
Vieira, Renata Teles
Rocha, Susana A
Telles-Correia, Diogo
Paes, Flávia
Yuan, Tifei
Nardi, Antonio Egidio
Arias-Carrión, Oscar
Machado, Sergio
Caixeta, Leonardo
Palavras-chave: Alzheimer Disease
Cholinesterase Inhibitors
Cognition Disorders
Humans
N-Methylaspartate
Data: Mar-2016
Resumo: The growing and aging population has contributed to the increased prevalence of Alzheimer's disease (AD) and other types of dementia in the world. AD is a progressive and degenerative brain disease with an onset characterized by episodic memory impairments, although progressive deficits can be observed in several domains including language, executive functions, attention and working memory. The relationship between cognitive impairments and the topography and progression of brain neuropathology is well established. The pathophysiologic mechanisms and processes that underline the course of cognitive and clinical decline have been the theoretical support for the development of pharmacological treatments for AD. Cholinesterase inhibitors (ChEIs) and N-methyl-D-aspartate (NMDA) antagonists are the main drugs used in the management of global cognitive impairment and several studies also explore the effects of both in specific cognitive measures. Recent research trends also examine the effects of combination therapy using both compounds. This review aims to update practical recommendations for the treatment of global cognitive functioning and specific neurocognitive deficits in AD using ChEIs, NMDA antagonists and combination therapy with both drugs.
Peer review: yes
URI: http://hdl.handle.net/10400.22/9465
Aparece nas colecções:ISCAP - Gestão - Artigos
ESS - TO - Artigos

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