Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/9107
Título: Longitudinal analysis of tumor marker CEA of breast cancer patients from Braga's hospital
Autor: Borges, Ana
Sousa, Inês
Castro, Luís
Palavras-chave: breast cancer
carcinoembryonic antigen
longitudinal models
Data: Mar-2015
Resumo: Allied to an epidemiological study of population of the Senology Unit of Braga’s Hospital that have been diagnosed with malignant breast cancer, we describe the progression in time of repeated measurements of tumor marker Carcinoembryonicantigen (CEA). Our mainpurpose is to describe the progression of this tumor markeras a function of possible risk factors and, hence, to understand how these risk factorsinfluences that progression. The response variable, values of CEA, was analyzedmaking use of longitudinal models, testing for different correlation structures. Thesame covariates used in a previous survival analysis were considered in the longitudinal model. The reference time used was time from diagnose until death from breast cancer. For diagnostic of the models fitted we have used empirical and theoretical variograms.To evaluate the fixed term of the longitudinal model we have tested for a changingpoint on the effect of time on the tumor marker progression. A longitudinal modelwas also fitted only to the subset of patients that died from breast cancer, using thereference time as time from date of death until blood test.
URI: http://hdl.handle.net/10400.22/9107
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