Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/7486
Título: Characterization of an antioxidant surfactant-free topical formulation containing Castanea sativa leaf extract
Autor: Almeida, Isabel F.
Maleckova, Jitka
Saffi, Raquel
Monteiro, Helena
Góios, Filipa
Amaral, Maria Helena
Costa, Paulo Cardoso
Garrido, Jorge
Silva, Paulo
Pestana, Nazaré
Bahia, Maria Fernanda
Palavras-chave: Antioxidant
Castanea sativa
Skin moisturization
Stability
Surfactant-free formulation
Data: 2015
Editora: Taylor & Francis
Relatório da Série N.º: Drug Development and Industrial Pharmacy;Vol. 41, Issue 1
Resumo: Context: Inclusion of antioxidants in topical formulations can contribute to minimize oxidative stress in the skin, which has been associated with photoaging, several dermatosis and cancer. Objective: A Castanea sativa leaf extract with established antioxidant activity was incorporated into a semisolid surfactant-free formulation. The objective of this study was to perform a comprehensive characterization of this formulation. Materials and methods: Physical, microbiological and functional stability were evaluated during 6 months storage at 20 °C and 40 °C. Microstructure elucidation (cryo-SEM), in vitro release and in vivo moisturizing effect (Corneometer® CM 825) were also assessed. Results and discussion: Minor changes were observed in the textural and rheological properties of the formulation when stored at 20 °C for 6 months and the antioxidant activity of the plant extract remained constant throughout the storage period. Microbiological quality was confirmed at the end of the study. Under accelerated conditions, higher modifications of the evaluated parameters were observed. Cryo-SEM analysis revealed the presence of oil droplets dispersed into a gelified external phase. The release rate of the antioxidant compounds (610 ± 70 µgh−0.5) followed Higuchi model. A significant in vivo moisturizing effect was demonstrated, that lasted at least 4 h after product’s application. Conclusion: The physical, functional and microbiological stability of the antioxidant formulation was established. Specific storage conditions should be recommended considering the influence of temperature on the stability. A skin hydration effect and good skin tolerance were also found which suggests that this preparation can be useful in the prevention or treatment of oxidative stress-mediated dysfunctions.
URI: http://hdl.handle.net/10400.22/7486
DOI: 10.3109/03639045.2013.850712
ISSN: 0363-9045
Versão do Editor: http://www.tandfonline.com/doi/abs/10.3109/03639045.2013.850712#
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