Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/7481
Título: Exploring cinnamic acid scaffold: development of promising neuroprotective lipophilic antioxidants
Autor: Chavarria, Daniel
Silva, Tiago
Martins, Daniel
Bravo, Joana
Summavielle, Teresa
Garrido, Jorge
Borges, Fernanda
Data: 2015
Editora: Royal Society of Chemistry
Relatório da Série N.º: MedChemComm;Issue 6, 2015
Resumo: New lipophilic hydroxycinnamic acid based derivatives were designed and synthesized and their antioxidant and neuroprotective activities evaluated. The chemical modification introduced in the cinnamic acid scaffold leads to compounds with amplified lipophilicity and in general with increased antioxidant activity when compared to natural models (caffeic and ferulic acids). The compounds did not display cytotoxicity and present a significant neuroprotective effect against 6-OH-DA induced damage to SH-SY5Y cells. Compound 6 stands out as an efficient radical scavenger and iron(II) chelator that ensures drug-like properties. Moreover, neuroprotection against oxidative damage was observed even at low concentration (1 μM). Therefore, compound 6 developed by a biology-oriented approach displays a combination of important features for a further optimization process that will generate a new effective antioxidant with therapeutic application for oxidative-stress-related events, namely neurodegenerative diseases.
URI: http://hdl.handle.net/10400.22/7481
DOI: 10.1039/C5MD00018A
Versão do Editor: http://pubs.rsc.org/en/content/articlelanding/2015/md/c5md00018a/unauth#!divAbstract
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