Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/7336
Título: Detrimental role of prolonged sleep deprivation on adult neurogenesis
Autor: Fernandes, Carina
Rocha, Nuno Barbosa F
Rocha, Susana
Herrera-Solís, Andrea
Salas-Pacheco, José
García-García, Fabio
Murillo-Rodríguez, Eric
Yuan, Ti-Fei
Machado, Sergio
Arias-Carrión, Oscar
Palavras-chave: sleep
adult neurogenesis
hypnotic drugs
antidepressants
circadian rhythms
hippocampus
Data: 2015
Resumo: Adult mammalian brains continuously generate new neurons, a phenomenon called adult neurogenesis. Both environmental stimuli and endogenous factors are important regulators of adult neurogenesis. Sleep has an important role in normal brain physiology and its disturbance causes very stressful conditions, which disrupt normal brain physiology. Recently, an influence of sleep in adult neurogenesis has been established, mainly based on sleep deprivation studies. This review provides an overview on how rhythms and sleep cycles regulate hippocampal and subventricular zone neurogenesis, discussing some potential underlying mechanisms. In addition, our review highlights some interacting points between sleep and adult neurogenesis in brain function, such as learning, memory, and mood states, and provides some insights on the effects of antidepressants and hypnotic drugs on adult neurogenesis.
Peer review: yes
URI: http://hdl.handle.net/10400.22/7336
DOI: 10.3389/fncel.2015.00140
Versão do Editor: http://journal.frontiersin.org/article/10.3389/fncel.2015.00140/abstract
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