Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/7249
Título: Development of a SPE–UHPLC–MS/MS methodology for thedetermination of non-steroidal anti-inflammatory and analgesicpharmaceuticals in seawaterPaula
Autor: Paíga, Paula
Lolić, Aleksandar
Hellebuyck, Floris
Santos, Lúcia H.M.L.M.
Correia, Manuela
Delerue-Matos, Cristina
Palavras-chave: Non-steroidal anti-inflammatory drugs
Analgesics
UHPLC–MS/MSSPE
Seawater
Data: Mar-2015
Editora: Elsevier
Relatório da Série N.º: Journal of Pharmaceutical and Biomedical Analysis;Vol. 106
Resumo: An analytical methodology for the simultaneous determination of seven pharmaceuticals and two metabolites belonging to the non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics therapeutic groups was developed based on off-line solid-phase extraction and ultra-high performance liquid chromatography coupled to tandem mass spectrometry (SPE–UHPLC–MS/MS). Extraction conditions were optimized taking into account parameters like sorbent material, sample volume and sample pH. Method detection limits (MDLs) ranging from 0.02 to 8.18 ng/L were obtained. This methodology was successfully applied to the determination of the selected pharmaceuticals in seawater samples of Atlantic Ocean in the Northern Portuguese coast. All the pharmaceuticals have been detected in the seawater samples, with pharmaceuticals like ibuprofen, acetaminophen, ketoprofen and the metabolite hydroxyibuprofen being the most frequently detected at concentrations that can reach some hundreds of ng/L.
URI: http://hdl.handle.net/10400.22/7249
DOI: 10.1016/j.jpba.2014.06.017
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S0731708514003057
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