Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/7240
Título: Molecularly imprinted sensor for voltammetric detection of norfloxacin
Autor: Silva, Hélder da
Pacheco, João
Silva, Joana
Viswanathan, Subramanian
Delerue-Matos, Cristina
Palavras-chave: Norfloxacin
Electrochemical sensor
Molecularly imprinted polymer
Multi-walled carbon nanotubes
Data: Nov-2015
Editora: Elsevier
Relatório da Série N.º: Sensors and Actuators B: Chemical;Vol. 219
Resumo: In this work, a norfloxacin selective modified glassy carbon electrode (GCE) based on a molecularly imprinted polymer (MIP) as electrochemical sensor was developed. A suspension of multi-walled carbon nanotubes (MWCNTs) was deposited on the electrode surface. Subsequently, a molecularly imprinted film was prepared by electropolymerization, via cyclic voltammetry of pyrrole (PPy) in the presence of norfloxacin (NFX) as the template molecule. A control electrode (NIP) was also prepared. Scanning electron microscopy (SEM) and cyclic voltammetry in a ferrocyanide solution were performed for morphological and electrochemical characterisation, respectively. Several experimental parameters were studied and optimised. For quantification purposes the MIP/MWCNT/GCE was immersed in NFX solutions for 10 min, and the detection was performed in voltammetric cell by square wave voltammetry. The proposed sensor presented a linear behaviour, between peak current intensity and logarithmic concentration of NFX between 1 × 10−7 and 8 × 10−6 M. The obtained results presented good precision, with a repeatability of 4.3% and reproducibility of 9% and the detection limit was 4.6 × 10−8 M (S/N = 3). The developed sensor displayed good selectivity and operational lifetime, is simple to fabricate and easy to operate and was successfully applied to the analysis of NFX in urine samples.
URI: http://hdl.handle.net/10400.22/7240
DOI: 10.1016/j.snb.2015.04.125
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S0925400515006097
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