Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/7041
Título: ß-Lactams: chemical structure, mode of action and mechanisms of resistance
Autor: Fernandes, Rúben
Amador, Paula
Prudêncio, Cristina
Data: 2013
Editora: Wolters Kluwer Health | Lippincott Williams & Wilkins
Citação: Fernandes, Rúben; Amador, Paula; Prudêncio, Cristina. ß-Lactams: chemical structure, mode of action and mechanisms of resistance, Reviews in Medical Microbiology, 24, 1, 7-17, 2013.
Resumo: This synopsis summarizes the key chemical and bacteriological characteristics of β-lactams, penicillins, cephalosporins, carbanpenems, monobactams and others. Particular notice is given to first-generation to fifth-generation cephalosporins. This review also summarizes the main resistance mechanism to antibiotics, focusing particular attention to those conferring resistance to broad-spectrum cephalosporins by means of production of emerging cephalosporinases (extended-spectrum β-lactamases and AmpC β-lactamases), target alteration (penicillin-binding proteins from methicillin-resistant Staphylococcus aureus) and membrane transporters that pump β-lactams out of the bacterial cell.
URI: http://hdl.handle.net/10400.22/7041
DOI: 10.1097/MRM.0b013e3283587727
Versão do Editor: http://journals.lww.com/revmedmicrobiol/Abstract/2013/01000/__Lactams___chemical_structure,_mode_of_action_and.2.aspx
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