Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/6087
Título: Osteoporotic hip fractures: Bisphosphonates sales and observed turning point in trend. A population-based retrospective study
Autor: Alves, Sandra Maria
Economou, Theodoros
Oliveira, Carla
Ribeiro, Ana Isabel
Neves, Nuno
Goméz-Barrena, Enrique
Pina, Maria Fátima
Palavras-chave: Bisphosphonates
Osteoporosis
Hip fractures
Anti-osteoporotic medication
Population studies
Data: 2013
Editora: Elsevier
Resumo: The aim is to examine the temporal trends of hip fracture incidence in Portugal by sex and age groups, and explore the relation with anti-osteoporotic medication. From the National Hospital Discharge Database, we selected from 1st January 2000 to 31st December 2008, 77,083 hospital admissions (77.4% women) caused by osteoporotic hip fractures (low energy, patients over 49 years-age), with diagnosis codes 820.x of ICD 9-CM. The 2001 Portuguese population was used as standard to calculate direct age-standardized incidence rates (ASIR) (100,000 inhabitants). Generalized additive and linear models were used to evaluate and quantify temporal trends of age specific rates (AR), by sex. We identified 2003 as a turning point in the trend of ASIR of hip fractures in women. After 2003, the ASIR in women decreased on average by 10.3 cases/100,000 inhabitants, 95% CI (− 15.7 to − 4.8), per 100,000 anti-osteoporotic medication packages sold. For women aged 65–69 and 75–79 we identified the same turning point. However, for women aged over 80, the year 2004 marked a change in the trend, from an increase to a decrease. Among the population aged 70–74 a linear decrease of incidence rate (95% CI) was observed in both sexes, higher for women: − 28.0% (− 36.2 to − 19.5) change vs − 18.8%, (− 32.6 to − 2.3). The abrupt turning point in the trend of ASIR of hip fractures in women is compatible with an intervention, such as a medication. The trends were different according to gender and age group, but compatible with the pattern of bisphosphonates sales.
Peer review: yes
URI: http://hdl.handle.net/10400.22/6087
DOI: 10.1016/j.bone.2012.12.014
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S8756328212014329
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