Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/5490
Título: Quinoxaline, its derivatives and applications: A state of the art review.
Autor: Pereira, Joana
Pessoa, Ana M.
Cordeiro, M. Natália S.
Fernandes, Rúben
Prudêncio, Cristina
Noronha, João Paulo
Vieira, Mónica
Palavras-chave: Quinoxaline
Quinoxaline derivatives
Biological activity
Therapeutic application
Biomedical applications
Data: 1-Jul-2014
Editora: European Journal of Medicinal Chemistry
Resumo: Quinoxaline derivatives are an important class of heterocycle compounds, where N replaces some carbon atoms in the ring of naphthalene. Its molecular formula is C8H6N2, formed by the fusion of two aromatic rings, benzene and pyrazine. It is rare in natural state, but their synthesis is easy to perform. In this review the State of the Art will be presented, which includes a summary of the progress made over the past years in the knowledge of the structure and mechanism of the quinoxaline and quinoxaline derivatives, associated medical and biomedical value as well as industrial value. Modifying quinoxaline structure it is possible to obtain a wide variety of biomedical applications, namely antimicrobial activities and chronic and metabolic diseases treatment.
Peer review: yes
URI: http://hdl.handle.net/10400.22/5490
DOI: 10.1016/j.ejmech.2014.06.058
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S022352341400587X
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