Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/5440
Título: Nanotechnology and antioxidant therapy: An emerging approach for neurodegenerative diseases
Autor: Fernandes, Carlos
Oliveira, Catarina
Benfeito, Sofia
Soares, Pedro
Garrido, Jorge
Borges, Fernanda
Palavras-chave: Dietary antioxidants
Nanocarriers
Neurodegenerative diseases
Oxidative-stress related diseases
Data: Dez-2014
Editora: Bentham
Relatório da Série N.º: Current Medicinal Chemistry;Vol. 21, issue 38
Resumo: The efficacy, cellular uptake and specific transport of dietary antioxidants to target organs, tissues and cells remains the most important setback for their application in the treatment of oxidative-stress related disorders and in particular in neurodegenerative diseases, as brain targeting remains a still unsolved challenge. Nanotechnology based delivery systems can be a solution for the above mentioned problems, specifically in the case of targeting dietary antioxidants with neuroprotective activity. Nanotechnology-based delivery systems can protect antioxidants from degradation, improve their physicochemical drug-like properties and in turn their bioavailability. The impact of nanomedicine in the improvement of the performance of dietary antioxidants, as protective agents in oxidative- stress events, specifically through the use of drug delivery systems, is highlighted in this review as well as the type of nanomaterials regularly used for drug delivery purposes. From the data one can conclude that the research combining (dietary) antioxidants and nanotechnology, namely as a therapeutic solution for neurodegenerative diseases, is still in a very early stage. So, a huge research area remains to be explored that hopefully will yield new and effective neuroprotective therapeutic agents in a foreseeable future.
Peer review: yes
URI: http://hdl.handle.net/10400.22/5440
DOI: 10.2174/0929867321666140915141836
Versão do Editor: http://benthamscience.com/journal/abstracts.php?journalID=cmc&articleID=124595
Aparece nas colecções:ISEP – DEQ – Artigos

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