Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/5435
Título: Microencapsulation of herbicide MCPA with native beta-cyclodextrin and its methyl and hydroxypropyl derivatives: An experimental and theoretical investigation
Autor: Garrido, Jorge
Cagide, Fernando
Melle-Franco, Manuel
Borges, Fernanda
Garrido, E. Manuela
Palavras-chave: Phenoxyacetic acid herbicides
Inclusion complex
Data: 5-Mar-2014
Editora: Elsevier
Relatório da Série N.º: Journal of Molecular Structure;Vol. 1061
Resumo: When a pesticide is released into the environment, most of it is lost before it reaches its target. An effective way to reduce environmental losses of pesticides is by using controlled release technology. Microencapsulation becomes a promising technique for the production of controlled release agricultural formulations. In this work, the microencapsulation of chlorophenoxy herbicide MCPA with native b-cyclodextrin and its methyl and hydroxypropyl derivatives was investigated. The phase solubility study showed that both native and b-CD derivatives increased the water solubility of the herbicide and inclusion complexes are formed in a stoichiometric ratio of 1:1. The stability constants describing the extent of formation of the complexes have been determined by phase solubility studies. 1H NMR experiments were also accomplished for the prepared solid systems and the data gathered confirm the formation of the inclusion complexes. 1H NMR data obtained for the MCPA/CDs complexes disclosed noticeable proton shift displacements for OCH2 group and H6 aromatic proton of MCPA provided clear evidence of inclusion complexation process, suggesting that the phenyl moiety of the herbicide was included in the hydrophobic cavity of CDs. Free energy molecular mechanics calculations confirm all these findings. The gathered results can be regarded as an essential step to the development of controlled release agricultural formulations containing herbicide MCPA.
Peer review: yes
URI: http://hdl.handle.net/10400.22/5435
DOI: 10.1016/j.molstruc.2013.12.067
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S0022286013011010
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