Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/5325
Título: Impact of excipients in the chronic toxicity of fluoxetine on the alga Chlorella vulgaris
Autor: Silva, Aurora
Santos, Lúcia
Delerue-Matos, Cristina
Figueiredo, Sónia Adriana
Palavras-chave: Antidepressant
Chlorella vulgaris
Data: 2014
Editora: Taylor & Francis
Relatório da Série N.º: Environmental Technology;Vol. 35, Issue 24
Resumo: Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) widely used in the treatment of major depression. It has been detected in surface and wastewaters, being able to negatively affect aquatic organisms. Most of the ecotoxicity studies focused only in pharmaceuticals, though excipients can also pose a risk to non-target organisms. In this work the ecotoxicity of five medicines (three generic formulations and two brand labels) containing the same active substance (fluoxetine hydrochloride) was tested on the alga Chlorella vulgaris, in order to evaluate if excipients can influence their ecotoxicity. Effective concentrations that cause 50% of inhibition (EC50) ranging from 0.25 to 15 mg L−1 were obtained in the growth inhibition test performed for the different medicines. The corresponding values for fluoxetine concentration are 10 times lower. Higher EC50 values had been published for the same alga considering only the toxicity of fluoxetine. Therefore, this increase in toxicity may be attributed to the presence of excipients. Thus more studies on ecotoxicological effects of excipients are required in order to assess the environmental risk they may pose to aquatic organisms.
Peer review: yes
URI: http://hdl.handle.net/10400.22/5325
DOI: 10.1080/09593330.2014.932438
Versão do Editor: http://www.tandfonline.com/doi/abs/10.1080/09593330.2014.932438#.VKEh5fmOA
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