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Advisor(s)
Abstract(s)
The electrooxidative behavior of pravastatin (PRV) in aqueous media was studied by square-wave voltammetry at a glassycarbon
electrode (GCE) and at a screen-printed carbon electrode (SPCE). Maximum peak current intensities in a pH 5.0 buffer were
obtained at +1.3 V vs. AgCl/Ag and +1.0 V vs. Ag for the GCE and SPCE surface respectively. Validation of the developed methodologies
revealed good performance characteristics and confirmed their applicability to the quantification of PRV in pharmaceutical
products, without significant sample pretreatment. A comparative analysis between the two electrode types showed that SPCEs are
preferred as an electrode surface because of their higher sensitivity and the elimination of the need to clean the electrode’s surface
for its renewal, which frequently is, if not always, the rate-limiting step in voltammetric analysis.
Description
Keywords
Pravastatin Square-wave voltammetry Electrochemical oxidation Glassy-carbon electrode Screen-printed carbon electrode