Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/4155
Título: Evaluation of solubility and partition properties of ampicillin-based ionic liquids
Autor: Florindo, Catarina
Araújo, João
Alves, Filipa
Matos, Carla
Ferraz, Ricardo
Prudêncio, Cristina
Noronha, João Paulo
Petrovski, Zeljko
Branco, Luís
Rebelo, Luís
Marrucho, Isabel
Palavras-chave: Active pharmaceutical ionic liquids
Critical micelle concentrations
Octanol–water partition coefficients
Bioavailability
Solubility
Data: 2013
Editora: Elsevier
Relatório da Série N.º: International Journal of Pharmaceutics; Vol. 456, Nº 2
Resumo: In order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected from substituted ammonium, phosphonium, pyridinium and methylimidazolium salts, with the intent of enhancing the solubility and bioavailability of l-ampicillin forms. In order to evaluate important properties of the synthesized API-ILs, the water solubility at 25 °C and 37 °C (body temperature) as well as octanol–water partition coefficients (Kow's) and HDPC micelles partition at 25 °C were measured. Critical micelle concentrations (CMC's) in water at 25 °C and 37 °C of the pharmaceutical ionic liquids bearing cations with surfactant properties were also determined from ionic conductivity measurements.
Peer review: yes
URI: http://hdl.handle.net/10400.22/4155
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S0378517313007321
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