Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/3596
Título: Post-surgical wound infections involving Enterobacteriaceae with reduced susceptibility to ß-lactams in two Portuguese hospitals
Autor: Fernandes, Rúben
Prudêncio, Cristina
Palavras-chave: Enterobacteriaceae
Extended-spectrum β-lactamases
Nosocomial infections
Post-surgical infections
Skin and soft tissue infections
Data: 2010
Editora: Blackwell Publishing Ltd and Medicalhelplines
Relatório da Série N.º: International Wound Journal; Vol. 7, Nº 6
Resumo: The post-surgical period is often critical for infection acquisition. The combination of patient injury and environmental exposure through breached skin add risk to pre-existing conditions such as drug or depressed immunity. Several factors such as the period of hospital staying after surgery, base disease, age, immune system condition, hygiene policies, careless prophylactic drug administration and physical conditions of the healthcare centre may contribute to the acquisition of a nosocomial infection. A purulent wound can become complicated whenever antimicrobial therapy becomes compromised. In this pilot study, we analysed Enterobacteriaceae strains, the most significant gram-negative rods that may occur in post-surgical skin and soft tissue infections (SSTI) presenting reduced β-lactam susceptibility and those presenting extended-spectrum β-lactamases (ESBL). There is little information in our country regarding the relationship between β-lactam susceptibility, ESBL and development of resistant strains of microorganisms in SSTI. Our main results indicate Escherichia coli and Klebsiella spp. are among the most frequent enterobacteria (46% and 30% respectively) with ESBL production in 72% of Enterobacteriaceae isolates from SSTI. Moreover, coinfection occurred extensively, mainly with Pseudomonas aeruginosa and Methicillin-resistant Staphylococcus aureus (18% and 13%, respectively). These results suggest future research to explore if and how these associations are involved in the development of antibiotic resistance.
Peer review: yes
URI: http://hdl.handle.net/10400.22/3596
ISSN: 17424801
Versão do Editor: http://onlinelibrary.wiley.com/doi/10.1111/j.1742-481X.2010.00723.x/abstract
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