Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/3593
Título: Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder
Autor: Junqueira-Neto, Susana
Vieira, Filipa Quintela
Montezuma, Diana
Costa, Natália R.
Antunes, Luís
Baptista, Tiago
Oliveira, Ana Isabel
Graça, Inês
Rodrigues, Ângelo
Magalhães, José S.
Oliveira, Jorge
Henrique, Rui
Jerónimo, Carmen
Palavras-chave: Bladder cancer
Class I HDACs
Apoptosis
Viability
Data: 2013
Editora: Wiley Periodicals
Relatório da Série N.º: Molecular Carcinogenesis; Vol. 53, Nº 2
Resumo: Deregulated expression of histone deacetylases (HDACs) has been implicated in tumorigenesis. Herein, we investigated class I HDACs expression in bladder urothelial cell carcinoma (BUCC), its prognostic value and biological significance. Significantly increased transcript levels of all HDACs were found in BUCC compared to 20 normal mucosas, and these were higher in lower grade and stage tumors. Increased HDAC3 levels were associated with improved patient survival. SiRNA experiments showed decrease cell viability and motility, and increased apoptosis. We concluded that class I HDACs play an important role in bladder carcinogenesis through deregulation of proliferation, migration and apoptosis, constituting putative therapeutic targets
Peer review: yes
URI: http://hdl.handle.net/10400.22/3593
ISSN: 0899-1987
Versão do Editor: http://onlinelibrary.wiley.com/doi/10.1002/mc.22117/abstract
Aparece nas colecções:ESTSP - CM - Artigos
ESS - APCT - Artigos

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