Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/3561
Título: β-Lactams: chemical structure, mode of action and mechanisms of resistance
Autor: Fernandes, Rúben
Amador, Paula
Prudêncio, Cristina
Palavras-chave: β-lactams
Chemical structure
Mechanisms of resistance
Mode of action
Data: 2013
Editora: Wolters Kluwer Health I Lippincott Williams & Wilkins
Relatório da Série N.º: Reviews in Medical Microbiology; Vol. 24, Nº 1
Resumo: This synopsis summarizes the key chemical and bacteriological characteristics of β-lactams, penicillins, cephalosporins, carbanpenems, monobactams and others. Particular notice is given to first-generation to fifth-generation cephalosporins. This reviewalso summarizes the main resistancemechanism to antibiotics, focusing particular attention to those conferring resistance to broad-spectrum cephalosporins by means of production of emerging cephalosporinases (extended-spectrum β-lactamases and AmpC β-lactamases), target alteration (penicillin-binding proteins from methicillin-resistant Staphylococcus aureus) and membrane transporters that pump β-lactams out of the bacterial cell.
Peer review: yes
URI: http://hdl.handle.net/10400.22/3561
ISSN: 0954-139X
Versão do Editor: http://journals.lww.com/revmedmicrobiol/Fulltext/2013/01000/__Lactams___chemical_structure,_mode_of_action_and.2.aspx
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