Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/3504
Título: Deregulated expression of selected histone methylases and demethylases in prostate carcinoma
Autor: Vieira, Filipa Quintela
Costa-Pinheiro, Pedro
Ramalho-Carvalho, João
Menezes, Francisco Duarte
Antunes, Luís
Carneiro, Isa
Oliveira, Jorge
Henrique, Rui
Jerónimo, Carmen
Palavras-chave: Prostate
Neoplasia
Molecular biology
Biomarker
Microarray
Data: 2013
Editora: Bioscientifica
Relatório da Série N.º: Endocrine-Related Cancer; Vol. 21, Nº 1
Resumo: Prostate cancer (PCa), a leading cause of cancer-related morbidity and mortality, arises through the acquisition of genetic and epigenetic alterations. Deregulation of histone methyltransferases (HMTs) or demethylases (HDMs) has been associated with PCa development and progression. However, the precise influence of altered HMTs or HDMs expression and respective histone marks in PCa onset and progression remains largely unknown. To clarify the role of HMTs and HDMs in prostate carcinogenesis, expression levels of 37 HMTs and 20 HDMs were assessed in normal prostate and PCa tissue samples by RT-qPCR. SMYD3, SUV39H2, PRMT6, KDM5A, and KDM6A were upregulated, whereas KMT2A-E (MLL1-5) and KDM4B were downregulated in PCa, compared with normal prostate tissues. Remarkably, PRMT6 was the histone modifier that best discriminated normal from tumorous tissue samples. Interestingly, EZH2 and SMYD3 expression levels significantly correlated with less differentiated and more aggressive tumors. Remarkably, SMYD3 expression levels were of independent prognostic value for the prediction of disease-specific survival of PCa patients with clinically localized disease submitted to radical prostatectomy. We concluded that expression profiling of HMTs and HDMs, especially SMYD3, might be of clinical usefulness for the assessment of PCa patients and assist in pre-therapeutic decision-making.
Peer review: yes
URI: http://hdl.handle.net/10400.22/3504
Versão do Editor: http://erc.endocrinology-journals.org/content/21/1/51.abstract
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