Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/3481
Título: Dermic diffusion and stratum corneum: a state of the art review of mathematical models
Autor: Couto, Ana
Fernandes, Ruben
Cordeiro, M. Natália D. S.
Reis, Sara S.
Ribeiro, Rogério T.
Pessoa, Ana S. Moura
Palavras-chave: Transdermal diffusion
Mathematical diffusion models
Fick's Law
Hybrid approach
Data: 2014
Editora: Elsevier
Citação: Couto, A., Fernandes, R., Cordeiro, M. N. S., Reis, S. S., Ribeiro, R. T., & Pessoa, A. M. (2014). Dermic diffusion and stratum corneum: A state of the art review of mathematical models. Journal of Controlled Release, 177, 74–83. doi:10.1016/j.jconrel.2013.12.005
Relatório da Série N.º: Journal of Controlled Release
Resumo: Transdermal biotechnologies are an ever increasing field of interest, due to the medical and pharmaceutical applications that they underlie. There are several mathematical models at use that permit a more inclusive vision of pure experimental data and even allow practical extrapolation for new dermal diffusion methodologies. However, they grasp a complex variety of theories and assumptions that allocate their use for specific situations. Models based on Fick's First Law found better use in contexts where scaled particle theory Models would be extensive in time-span but the reciprocal is also true, as context of transdermal diffusion of particular active compounds changes. This article reviews extensively the various theoretical methodologies for studying dermic diffusion in the rate limiting dermic barrier, the stratum corneum, and systematizes its characteristics, their proper context of application, advantages and limitations, as well as future perspectives.
Peer review: yes
URI: http://hdl.handle.net/10400.22/3481
ISSN: 0168-3659
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S0168365913009474
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