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Abstract(s)
Thiodicarb, a carbamate pesticide widely used on crops, may pose several environmental
and health concerns. This study aimed to explore its toxicological profile on male rats using
hematological, biochemical, histopathological, and flow cytometry markers. Exposed animals
were dosed daily at 10, 20, or 40 mg/kg/body weight (group A, B, and C, respectively) during
30 d. No significant changes were observed in hematological parameters among all groups.
After 10 d, a decrease of total cholesterol levels was noted in rats exposed to 40 mg/kg.
Aspartate aminotransferase (AST) activity increased (group A at 20 d; groups A and B at
30 d) and alkaline phosphatase (ALP) (group B at 30 d) activity significantly reduced. At 30 d
a decrease of some of the other evaluated parameters was observed with total cholesterol
and urea levels in group A as well as total protein and creatinine levels in groups A and
B. Histological results demonstrated multi-organ dose-related damage in thiodicarb-exposed
animals, evidenced as hemorrhagic and diffuse vacuolation in hepatic tissue; renal histology
showed disorganized glomeruli and tubular cell degeneration; spleen was ruptured with white
pulp and clusters of iron deposits within red pulp; significant cellular loss was noted at the
cortex of thymus; and degenerative changes were observed within testis. The histopathologic
alterations were most prominent in the high-dose group. Concerning flow cytometry studies,
an increase of lymphocyte number, especially T lymphocytes, was seen in blood samples from
animals exposed to the highest dose. Taken together, these results indicate marked systemic
organ toxicity in rats after subacute exposure to thiodicarb.
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Taylor & Francis