Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/3271
Título: Exploring bioactive properties of marine cyanobacteria Isolated from the Portuguese coast: high potential as a source of anticancer compounds
Autor: Costa, Margarida
Garcia, Mónica
Costa-Rodrigues, João
Costa, Maria Sofia
Ribeiro, Maria João
Fernandes, Maria Helena
Barros, Piedade
Barreiro, Aldo
Vasconcelos, Vítor
Martins, Rosário
Palavras-chave: Marine cyanobacteria
Natural products
Anticancer potential
Data: 2014
Editora: Marine Drugs
Resumo: The oceans remain a major source of natural compounds with potential in pharmacology. In particular, during the last few decades, marine cyanobacteria have been in focus as producers of interesting bioactive compounds, especially for the treatment of cancer. In this study, the anticancer potential of extracts from twenty eight marine cyanobacteria strains, belonging to the underexplored picoplanktonic genera, Cyanobium, Synechocystis and Synechococcus, and the filamentous genera, Nodosilinea, Leptolyngbya, Pseudanabaena and Romeria, were assessed in eight human tumor cell lines. First, a crude extract was obtained by dichloromethane:methanol extraction, and from it, three fractions were separated in a Si column chromatography. The crude extract and fractions were tested in eight human cancer cell lines for cell viability/toxicity, accessed with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and lactic dehydrogenase release (LDH) assays. Eight point nine percent of the strains revealed strong cytotoxicity; 17.8% showed moderate cytotoxicity, and 14.3% assays showed low toxicity. The results obtained revealed that the studied genera of marine cyanobacteria are a promising source of novel compounds with potential anticancer activity and highlight the interest in also exploring the smaller filamentous and picoplanktonic genera of cyanobacteria.
Peer review: yes
URI: http://hdl.handle.net/10400.22/3271
ISSN: 1660-3397
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