Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/3173
Título: Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced bladder tumours
Autor: Ferreira, José Alexandre
Videira, Paula
Lima, Luís
Pereira, Sofia
Silva, Mariana
Carrascal, Milene
Severino, Paulo
Fernandes, Elisabete
Almeida, Andreia
Costa, Céu
Vitorino, Rui
Amaro, Teresina
Oliveira, Maria José
Reis, Celso
Dall'Olio, Fabio
Amado, Francisco
Santos, Lúcio
Palavras-chave: Sialyl:Tn
Bladder cancer
Glycosylation
ST6GalNAc.I
Tumour-associated glycans
proliferative bladder cancer
Data: 2013
Editora: Elsevier
Relatório da Série N.º: Molecular Oncology; Vol. 7, Nº 3
Resumo: Little is known on the expression of the tumour-associated carbohydrate antigen sialyl-Tn (STn), in bladder cancer. We report here that 75% of the high-grade bladder tumours, presenting elevated proliferation rates and high risk of recurrence/progression expressed STn. However, it was mainly found in non-proliferative areas of the tumour, namely in cells invading the basal and muscle layers. STn was also found in tumour-adjacent mucosa, which suggests its dependence on a field effect of the tumour. Furthermore, it was not expressed by the normal urothelium, demonstrating the cancer-specific nature of this antigen. STn expression correlated with that of sialyltransferase ST6GalNAc.I, its major biosynthetic enzyme. The stable expression of ST6GalNAc.I in the bladder cancer cell line MCR induced STn expression and a concomitant increase of cell motility and invasive capability. Altogether, these results indicate for the first time a link between STn expression and malignancy in bladder cancer. Hence, therapies targeting STn may constitute new treatment approaches for these tumours.
Peer review: yes
URI: http://hdl.handle.net/10400.22/3173
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S1574789113000458
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