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New sensing materials of molecularly-imprinted polymers for the selective recognition of Chlortetracycline
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Orientador(es)
Resumo(s)
As a result of the stressful conditions in aquaculture facilities there is a high risk of bacterial infections among
cultured fish. Chlortetracycline (CTC) is one of the antimicrobials used to solve this problem. It is a broad
spectrum antibacterial active against a wide range of Gram-positive and Gram-negative bacteria. Numerous
analytical methods for screening, identifying, and quantifying CTC in animal products have been developed
over the years. An alternative and advantageous method should rely on expeditious and efficient procedures
providing highly specific and sensitive measurements in food samples. Ion-selective electrodes (ISEs) could
meet these criteria. The only ISE reported in literature for this purpose used traditional electro-active
materials. A selectivity enhancement could however be achieved after improving the analyte recognition by
molecularly imprinted polymers (MIPs).
Several MIP particles were synthesized and used as electro-active materials. ISEs based in methacrylic acid
monomers showed the best analytical performance according to slope (62.5 and 68.6 mV/decade) and
detection limit (4.1×10−5 and 5.5×10−5 mol L−1). The electrodes displayed good selectivity. The ISEs are not
affected by pH changes ranging from 2.5 to 13. The sensors were successfully applied to the analysis of serum,
urine and fish samples.
Descrição
Palavras-chave
Chlortetracycline Molecularly-imprinted sensors Potentiometry FIA Fish
Contexto Educativo
Citação
Editora
Elsevier