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Biomimetic sensors of molecularly-imprinted polymers for chlorpromazine determination
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Orientador(es)
Resumo(s)
A new man-tailored biomimetic sensor for Chlorpromazine host-guest interactions and potentiometric
transduction is presented. The artificial host was imprinted within methacrylic acid, 2-vinyl pyridine and
2-acrylamido-2-methyl-1-propanesulfonic acid based polymers. Molecularly imprinted particles were
dispersed in 2-nitrophenyloctyl ether and entrapped in a poly(vinyl chloride) matrix. Slopes and detection
limits ranged 51–67 mV/decade and 0.46–3.9 μg/mL, respectively, in steady state conditions. Sensors were
independent fromthe pHof test solutionswithin 2.0–5.5.Good selectivitywas observed towards oxytetracycline,
doxytetracycline, ciprofloxacin, enrofloxacin, nalidixic acid, sulfadiazine, trimethoprim, glycine, hydroxylamine,
cysteine and creatinine. Analytical features in flowing media were evaluated on a double-channel manifold,
with a carrier solution of 5.0×10−2 mol/L phosphate buffer. Near-Nernstian response was observed over the
concentration range 1.0×10−4 to 1.0×10−2 mol/L. Average slopes were about 48 mV/decade. The sensors were
successfully applied to field monitoring of CPZ in fish samples, offering the advantages of simplicity, accuracy,
automation feasibility and applicability to complex samples.
Descrição
Palavras-chave
Chlorpromazine Molecularly-imprinted sensors Potentiometry FIA Fish
Contexto Educativo
Citação
Editora
Elsevier