Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/3049
Título: Biomimetic sensors of molecularly-imprinted polymers for chlorpromazine determination
Autor: Moreira, Felismina T. C.
Sales, M. Goreti F.
Palavras-chave: Chlorpromazine
Molecularly-imprinted sensors
Data: 2011
Editora: Elsevier
Relatório da Série N.º: Materials Science and Engineering: C; Vol. 31, Issue 5
Resumo: A new man-tailored biomimetic sensor for Chlorpromazine host-guest interactions and potentiometric transduction is presented. The artificial host was imprinted within methacrylic acid, 2-vinyl pyridine and 2-acrylamido-2-methyl-1-propanesulfonic acid based polymers. Molecularly imprinted particles were dispersed in 2-nitrophenyloctyl ether and entrapped in a poly(vinyl chloride) matrix. Slopes and detection limits ranged 51–67 mV/decade and 0.46–3.9 μg/mL, respectively, in steady state conditions. Sensors were independent fromthe pHof test solutionswithin 2.0–5.5.Good selectivitywas observed towards oxytetracycline, doxytetracycline, ciprofloxacin, enrofloxacin, nalidixic acid, sulfadiazine, trimethoprim, glycine, hydroxylamine, cysteine and creatinine. Analytical features in flowing media were evaluated on a double-channel manifold, with a carrier solution of 5.0×10−2 mol/L phosphate buffer. Near-Nernstian response was observed over the concentration range 1.0×10−4 to 1.0×10−2 mol/L. Average slopes were about 48 mV/decade. The sensors were successfully applied to field monitoring of CPZ in fish samples, offering the advantages of simplicity, accuracy, automation feasibility and applicability to complex samples.
Peer review: yes
URI: http://hdl.handle.net/10400.22/3049
ISSN: 0928-4931
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S0928493111001172
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