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Publicação
Preservation of catechin antioxidant properties loaded in carbohydrate nanoparticles
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Orientador(es)
Resumo(s)
Epigallocatechin gallate (EGCG), an antioxidant with several pharmacological and biological activities,
was encapsulated in carbohydrate particles to preserve its antioxidant properties and improve its
bioavailability. Gum arabic–maltodextrin particles loaded with EGCG (EGCG/P) were successfully produced
by homogenization and spray-drying, with an EGCG loading efficiency of 96
±
3%. Spray-dried
particles are spherical or corrugated and polydisperse with diameters less than 20 m. The particles in
aqueous suspension revealed two main populations, with mean average diameters of 40 nm and 400 nm.
Attenuated total reflection-infrared spectroscopy (ATR-IR) confirmed that EGCG was incorporated in
the carbohydrate matrix by intermolecular interactions, maintaining its chemical integrity. Atomic force
microscopy imaging proved the particle spherical shape and size. The present study demonstrates that
the carbohydrate matrix is able to preserve EGCG antioxidant properties, as proof of concept to be used
as polymeric drug carrier.
Descrição
Palavras-chave
Epigallocatechin gallate Carbohydrates Particles Spray-drying Polymeric drug carrier
Contexto Educativo
Citação
Editora
Elsevier