Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/3032
Título: Man-tailored biomimetic sensor of molecularly imprinted materials for the potentiometric measurement of oxytetracycline
Autor: Moreira, Felismina T. C.
Kamel, Ayman H.
Guerreiro, J. Rafaela L.
Sales, M. Goreti F.
Palavras-chave: Molecularly imprinted sensors
Ion-selective electrodes
Flow-injection analysis
Data: 2010
Editora: Elsevier
Relatório da Série N.º: Biosensors and Bioelectronics; Vol.26, Issue 2
Resumo: A novel biomimetic sensor for the potentiometric transduction of oxytetracycline is presented. The artificial host was imprinted in methacrylic acid and/or acrylamide based polymers. Different amounts of molecularly imprinted and non-imprinted polymers were dispersed in different plasticizing solvents and entrapped in a poly(vinyl chloride) matrix. Only molecularly imprinted based sensors allowed a potentiometric transduction, suggesting the existence of host–guest interactions. These sensors exhibited a near-Nernstian response in steady state evaluations; slopes and detection limits ranged 42–63 mV/decade and 2.5–31.3 µg/mL, respectively. Sensors were independent from the pH of test solutions within 2–5. Good selectivity was observed towards glycine, ciprofloxacin, creatinine, acid nalidixic, sulfadiazine, cysteine, hydroxylamine and lactose. In flowing media, the biomimetic sensors presented good reproducibility (RSD of ±0.7%), fast response, good sensitivity (65 mV/decade), wide linear range (5.0×10−5 to 1.0×10−2 mol/L), low detection limit (19.8 µg/mL), and a stable baseline for a 5×10−3M citrate buffer (pH 2.5) carrier. The sensors were successfully applied to the analysis of drugs and urine. This work confirms the possibility of using molecularly imprinted polymers as ionophores for organic ion recognition in potentiometric transduction.
Peer review: yes
URI: http://hdl.handle.net/10400.22/3032
ISSN: 0956-5663
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S0956566310004112
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