Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/3007
Título: Electroanalytical study of the antidepressant sertraline
Autor: Nouws, Henri P. A.
Delerue-Matos, Cristina
Barros, Aquiles A.
Rodrigues, José A.
Palavras-chave: Flow injection
Hanging mercury drop electrode
Adsorptive stripping voltammetry
Sertraline
SSRI
Data: 2005
Editora: Elsevier
Relatório da Série N.º: Journal of Pharmaceutical and Biomedical Analysis; Vol.39, Issue 1-2
Resumo: Aflowinjection squarewave cathodic stripping voltammetric method has been developed for the determination of sertraline in a pharmaceutical preparation. The method shows linearity between peak current intensity and sertraline concentration for the interval between 0.20×10−6 and 1.20×10−6 mol L−1. Limits of detection and quantification were found to be 1.5×10−7 and 5.0×10−7 mol L−1, respectively. Up to 70 samples per hour can be analysed with a good precision (R.S.D. = 2.5%). The proposed method was successfully applied to the determination of sertraline in a commercial product. In the voltammetric determination of sertraline in flow, a high sample rate is obtained at reduced costs, opening the possibility to compete with the chromatographic methods generally used for this analysis.
Peer review: yes
URI: http://hdl.handle.net/10400.22/3007
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S0731708505001986#
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