Electroanalytical study of the antidepressant sertraline

Nouws, Henri P. A.; Delerue-Matos, Cristina; Barros, Aquiles A.; Rodrigues, José A.

http://hdl.handle.net/10400.22/3007

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Authors

Nouws, Henri P. A.

Delerue-Matos, Cristina

Barros, Aquiles A.

Rodrigues, José A.

Abstract(s)

Aflowinjection squarewave cathodic stripping voltammetric method has been developed for the determination of sertraline in a pharmaceutical preparation. The method shows linearity between peak current intensity and sertraline concentration for the interval between 0.20×10−6 and 1.20×10−6 mol L−1. Limits of detection and quantification were found to be 1.5×10−7 and 5.0×10−7 mol L−1, respectively. Up to 70 samples per hour can be analysed with a good precision (R.S.D. = 2.5%). The proposed method was successfully applied to the determination of sertraline in a commercial product. In the voltammetric determination of sertraline in flow, a high sample rate is obtained at reduced costs, opening the possibility to compete with the chromatographic methods generally used for this analysis.