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Advisor(s)
Abstract(s)
Aflowinjection squarewave cathodic stripping voltammetric method has been developed for the determination of sertraline in a pharmaceutical
preparation. The method shows linearity between peak current intensity and sertraline concentration for the interval between 0.20×10−6
and 1.20×10−6 mol L−1. Limits of detection and quantification were found to be 1.5×10−7 and 5.0×10−7 mol L−1, respectively. Up to 70
samples per hour can be analysed with a good precision (R.S.D. = 2.5%). The proposed method was successfully applied to the determination
of sertraline in a commercial product. In the voltammetric determination of sertraline in flow, a high sample rate is obtained at reduced costs,
opening the possibility to compete with the chromatographic methods generally used for this analysis.
Description
Keywords
Flow injection Hanging mercury drop electrode Adsorptive stripping voltammetry Sertraline SSRI
Citation
Publisher
Elsevier