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Publicação
Electroanalytical study of the antidepressant sertraline
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Orientador(es)
Resumo(s)
Aflowinjection squarewave cathodic stripping voltammetric method has been developed for the determination of sertraline in a pharmaceutical
preparation. The method shows linearity between peak current intensity and sertraline concentration for the interval between 0.20×10−6
and 1.20×10−6 mol L−1. Limits of detection and quantification were found to be 1.5×10−7 and 5.0×10−7 mol L−1, respectively. Up to 70
samples per hour can be analysed with a good precision (R.S.D. = 2.5%). The proposed method was successfully applied to the determination
of sertraline in a commercial product. In the voltammetric determination of sertraline in flow, a high sample rate is obtained at reduced costs,
opening the possibility to compete with the chromatographic methods generally used for this analysis.
Descrição
Palavras-chave
Flow injection Hanging mercury drop electrode Adsorptive stripping voltammetry Sertraline SSRI
Contexto Educativo
Citação
Editora
Elsevier