Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/3000
Título: Construction and evaluation of cysteine selective electrodes for FIA analysis of pharmaceuticals
Autor: Sales, M. Goreti F.
Pille, Annouschka
Paíga, Paula
Palavras-chave: Cysteine
Potentiometry
Ion-selective electrode
FIA and pharmaceuticals
Data: 2003
Editora: Taylor & Francis
Relatório da Série N.º: Analytical Letters; Vol. 36, Issue 14
Resumo: A flow injection analysis (FIA) system comprising a cysteine selective electrode as detection system was developed for determination of this amino acid in pharmaceuticals. Several electrodes were constructed for this purpose, having PVC membranes with different ionic exchangers and mediator solvents. Better working characteristics were attained with membranes comprising o-nitrophenyl octyl ether as mediator solvent and a tetraphenylborate based ionic-sensor. Injection of 500 µL standard solutions into an ionic strength adjuster carrier (3x10-3 M) of barium chloride flowing at 2.4mL min-1, showed linearity ranges from 5.0x10-5 to 5.0x10-3 M, with slopes of 76.4±0.6mV decade-1 and R2>0.9935. Slope decreased significantly under the requirement of a pH adjustment, selected at 4.5. Interference of several compounds (sodium, potassium, magnesium, barium, glucose, fructose, and sucrose) was estimated by potentiometric selectivity coefficients and considered negligible. Analysis of real samples were performed and considered accurate, with a relative error to an independent method of +2.7%.
Peer review: yes
URI: http://hdl.handle.net/10400.22/3000
Versão do Editor: http://www.tandfonline.com/doi/abs/10.1081/AL-120026412#.UpYNRkr6Q25
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