Flow injection electrochemical determination of apomorphine

Garrido, Jorge; Delerue-Matos, Cristina; Borges, Fernanda; Macedo, Tice R. A.; Oliveira-Brett, A. M.

http://hdl.handle.net/10400.22/2988

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Authors

Garrido, Jorge

Delerue-Matos, Cristina

Borges, Fernanda

Macedo, Tice R. A.

Oliveira-Brett, A. M.

Abstract(s)

Few analytical methods are currently available for determination of apomorphine, the active substance of a new oral formulation used in the treatment of erectile dysfunction. In this way a flow injection electrochemical method (FIA-EC) was developed for its quantification and applied to pharmaceutical dosage forms. Based in previous findings regarding the stability of apomorphine in borate buffer and after optimization of several analytical parameters a single channel flow injection manifold was set up that enables the determination of this drug over the concentration range of 3 to 16 µmol L-1 with a detection limit of 0.5 µmol L-1 at a sampling rateof 90 h-1. The simplicity and rapidity of the FIA-EC method used, its reproducibility and sensitivity make it suitable for quality control of pharmaceutical preparations of apomorphine intended for clinical use and research.