Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/2988
Título: Flow injection electrochemical determination of apomorphine
Autor: Garrido, Jorge
Delerue-Matos, Cristina
Borges, Fernanda
Macedo, Tice R. A.
Oliveira-Brett, A. M.
Palavras-chave: Apomorphine
Electrochemical detection
Flow injection
Data: 2003
Editora: Taylor & Francis
Relatório da Série N.º: Analytical Letters; Vol. 36, Issue 10
Resumo: Few analytical methods are currently available for determination of apomorphine, the active substance of a new oral formulation used in the treatment of erectile dysfunction. In this way a flow injection electrochemical method (FIA-EC) was developed for its quantification and applied to pharmaceutical dosage forms. Based in previous findings regarding the stability of apomorphine in borate buffer and after optimization of several analytical parameters a single channel flow injection manifold was set up that enables the determination of this drug over the concentration range of 3 to 16 µmol L-1 with a detection limit of 0.5 µmol L-1 at a sampling rateof 90 h-1. The simplicity and rapidity of the FIA-EC method used, its reproducibility and sensitivity make it suitable for quality control of pharmaceutical preparations of apomorphine intended for clinical use and research.
Peer review: yes
URI: http://hdl.handle.net/10400.22/2988
ISSN: 0003-2719
1532-236X
Versão do Editor: http://www.tandfonline.com/doi/abs/10.1081/AL-120023711#.Uon930r6Q24
Aparece nas colecções:ISEP – GRAQ – Artigos

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