Electrochemical determination of citalopram by adsorptive stripping voltammetry–determination in pharmaceutical products

Nouws, Henri P. A.; Delerue-Matos, Cristina; Barros, Aquiles A.

http://hdl.handle.net/10400.22/2969

Use this identifier to reference this record.

Name:	Description:	Size:	Format:
ART_HenriNouws_2006_GRAQ.pdf		111.15 KB	Adobe PDF	Download

Send Feedback

Authors

Nouws, Henri P. A.

Delerue-Matos, Cristina

Barros, Aquiles A.

Abstract(s)

The electrochemical behavior of citalopram was studied by square-wave and square-wave adsorptive-stripping voltammetry (SWAdSV). Citalopram can be reduced and accumulated at a mercury drop electrode, with a maximum peak current intensity being obtained at a potential of approximately -1.25V vs. AgCl/Ag, in an aqueous electrolyte solution of pH 12. A SWAdSV method has been developed for the determination of citalopram in pharmaceutical preparations. The method shows a linear range between 1.0x10-7 and 2.0x10-6 mol L-1 with a limit of detection of 5x10-8 mol L-1 for an accumulation time of 30 s. The precision of the method was evaluated by assessing the repeatability and intermediate precision, achieving good relative standard deviations in all cases (≤2.3%). The proposed method was applied to the determination of citalopram in five pharmaceutical products and the results obtained are in good agreement with the labeled values.