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Advisor(s)
Abstract(s)
The electrochemical behavior of citalopram was studied by square-wave and
square-wave adsorptive-stripping voltammetry (SWAdSV). Citalopram can be reduced
and accumulated at a mercury drop electrode, with a maximum peak current intensity
being obtained at a potential of approximately -1.25V vs. AgCl/Ag, in an aqueous
electrolyte solution of pH 12. A SWAdSV method has been developed for the
determination of citalopram in pharmaceutical preparations. The method shows a
linear range between 1.0x10-7 and 2.0x10-6 mol L-1 with a limit of detection
of 5x10-8 mol L-1 for an accumulation time of 30 s. The precision of the method
was evaluated by assessing the repeatability and intermediate precision, achieving
good relative standard deviations in all cases (≤2.3%). The proposed method was
applied to the determination of citalopram in five pharmaceutical products and the
results obtained are in good agreement with the labeled values.
Description
Keywords
Citalopram SSRI Hanging mercury drop electrode Adsorptive-stripping voltammetry Pharmaceutical analysis
Citation
Publisher
Taylor & Francis