Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/2969
Título: Electrochemical determination of citalopram by adsorptive stripping voltammetry–determination in pharmaceutical products
Autor: Nouws, Henri P. A.
Delerue-Matos, Cristina
Barros, Aquiles A.
Palavras-chave: Citalopram
Hanging mercury drop electrode
Adsorptive-stripping voltammetry
Pharmaceutical analysis
Data: 2006
Editora: Taylor & Francis
Relatório da Série N.º: Analytical Letters; Vol. 39, Issue 9
Resumo: The electrochemical behavior of citalopram was studied by square-wave and square-wave adsorptive-stripping voltammetry (SWAdSV). Citalopram can be reduced and accumulated at a mercury drop electrode, with a maximum peak current intensity being obtained at a potential of approximately -1.25V vs. AgCl/Ag, in an aqueous electrolyte solution of pH 12. A SWAdSV method has been developed for the determination of citalopram in pharmaceutical preparations. The method shows a linear range between 1.0x10-7 and 2.0x10-6 mol L-1 with a limit of detection of 5x10-8 mol L-1 for an accumulation time of 30 s. The precision of the method was evaluated by assessing the repeatability and intermediate precision, achieving good relative standard deviations in all cases (≤2.3%). The proposed method was applied to the determination of citalopram in five pharmaceutical products and the results obtained are in good agreement with the labeled values.
Peer review: yes
URI: http://hdl.handle.net/10400.22/2969
ISSN: 0003-2719
Versão do Editor: http://www.tandfonline.com/doi/abs/10.1080/00032710600721712#.UpS-J0r6Q25
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