Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/2964
Título: Square-wave adsorptive-stripping voltammetric detection in the quality control of fluoxetine
Autor: Nouws, Henri P. A.
Delerue-Matos, Cristina
Barros, Aquiles A.
Rodrigues, José A.
Santos-Silva, Alice
Borges, Fernanda
Palavras-chave: Fluoxetine
Square-wave adsorptive-stripping voltammetry
Flow-injection analysis
Electrochemical detection
Drug dissolution
Data: 2007
Editora: Taylor & Francis
Relatório da Série N.º: Analytical Letters; Vol. 40, Issue 6
Resumo: Electroanalytical methods based on square-wave adsorptive-stripping voltammetry (SWAdSV) and flow-injection analysis with square-wave adsorptive-stripping voltammetric detection (FIA-SWAdSV) were developed for the determination of fluoxetine (FXT). The methods were based on the reduction of FXT at a mercury drop electrode at -1.2 V versus Ag/AgCl, in a phosphate buffer of pH 12.0, and on the possibility of accumulating the compound at the electrode surface. The SWAdSV method was successfully applied in the quantification of FXT in pharmaceutical products, human serum samples, and in drug dissolution studies. Because the presence of dissolved oxygen did not interfere significantly with the analysis, it was possible to quantify FXT in several pharmaceutical products using FIA-SWAdSV. This method enables analysis of up to 120 samples per hour at reduced costs.
Peer review: yes
URI: http://hdl.handle.net/10400.22/2964
ISSN: 0003-2719
1532-236X
Versão do Editor: http://www.tandfonline.com/doi/abs/10.1080/00032710701297059#.UpTIp0r6Q25
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