Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/2960
Título: Electroanalytical determination of codeine in pharmaceutical preparations
Autor: Garrido, Jorge
Delerue-Matos, Cristina
Borges, Fernanda
Macedo, Tice R. A.
Oliveira-Brett, A. M.
Palavras-chave: Codeine
Square wave voltammetry
Flow injection analysis with electrochemical detection
Acetaminophen
Guaiacol
Parabens
Ephedrine
Acetylsalicylic acid
Caffeine
Data: 2002
Editora: Taylor & Francis
Relatório da Série N.º: Analytical Letters; Vol. 35, Issue 15
Resumo: A square wave voltammetric (SWV) method and a flow injection analysis systemwi th electrochemical detection (FIA-EC) using a glassy carbon electrode were evaluated for the determination of codeine in pharmaceutical preparations. The interference of several compounds, such as acetaminophen,guaiacol, parabens, ephedrine, acetylsalicylic acid and caffeine, that usually appear associated with codeine pharmaceutical preparations was studied. It was verified that these electroanalytical methods could not be used with acetaminophen present in the formulations and that with guaiacol, parabens or ephedrine present the use of the FIA-EC system was impracticable. A detection limit of 5 µmol L- 1 and a linear calibration range from 40 to 140 µmol L- 1 was obtained with the SWV method. For the flow injection analysis procedure a linear calibration range was obtained from 7 to 50 µmol L- 1 with a detection limit of 3 µmol L- 1 and the FIA-EC systemallowed a sampling rate of 115 samples per hour. The results obtained by the two methods, SWV and FIA-EC, were compared with those obtained using reference methods and demonstrated good agreement, with relative deviations lower than 4%.
Peer review: yes
URI: http://hdl.handle.net/10400.22/2960
Versão do Editor: http://www.tandfonline.com/doi/abs/10.1081/AL-120016539#.UpSpk0r6Q25
Aparece nas colecções:ISEP – GRAQ – Artigos

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
ART_TiceMacedo_2002_GRAQ.pdf513,68 kBAdobe PDFVer/Abrir


FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.