Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/2951
Título: Direct electroanalytical determination of fluvastatin in a pharmaceutical dosage form: batch and flow analysis
Autor: Neves, Marta M. P. S.
Nouws, Henri P. A.
Delerue-Matos, Cristina
Palavras-chave: Adsorptive-stripping voltammetry
Amperometric detection
Flow injection analysis
Fluvastatin
Hanging mercury drop electrode
Pharmaceutical analysis
Data: 2008
Editora: Taylor & Francis
Relatório da Série N.º: Analytical Letters; Vol. 41, Issue 15
Resumo: The reduction of luvastatin (FLV) at a hanging mercury-drop electrode (HMDE) was studied by square-wave adsorptive-stripping voltammetry (SWAdSV). FLV can be accumulated and reduced at the electrode, with a maximum peak current intensity at a potential of approximately 1.26V vs. AgCl=Ag, in an aqueous electrolyte solution of pH 5.25. The method shows linearity between peak current intensity and FLV concentration between 1.0 10 8 and 2.7 10 6 mol L 1. Limits of detection (LOD) and quantification (LOQ) were found to be 9.9 10 9 mol L 1 and 3.3 10 8 mol L 1, respectively. Furthermore, FLV oxidation at a glassy carbon electrode surface was used for its hydrodynamic monitoring by amperometric detection in a flow-injection system. The amperometric signal was linear with FLV concentration over the range 1.0 10 6 to 1.0 10 5 mol L 1, with an LOD of 2.4 10 7 mol L 1 and an LOQ of 8.0 10 7 mol L 1. A sample rate of 50 injections per hour was achieved. Both methods were validated and showed to be precise and accurate, being satisfactorily applied to the determination of FLV in a commercial pharmaceutical.
Peer review: yes
URI: http://hdl.handle.net/10400.22/2951
ISSN: 0003-2719
1532-236X
Versão do Editor: http://www.tandfonline.com/doi/abs/10.1080/00032710802421889#.UooaQH9qyZQ
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