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|Título:||Direct electroanalytical determination of fluvastatin in a pharmaceutical dosage form: batch and flow analysis|
|Autor:||Neves, Marta M. P. S.|
Nouws, Henri P. A.
Flow injection analysis
Hanging mercury drop electrode
|Editora:||Taylor & Francis|
|Relatório da Série N.º:||Analytical Letters; Vol. 41, Issue 15|
|Resumo:||The reduction of luvastatin (FLV) at a hanging mercury-drop electrode (HMDE) was studied by square-wave adsorptive-stripping voltammetry (SWAdSV). FLV can be accumulated and reduced at the electrode, with a maximum peak current intensity at a potential of approximately 1.26V vs. AgCl=Ag, in an aqueous electrolyte solution of pH 5.25. The method shows linearity between peak current intensity and FLV concentration between 1.0 10 8 and 2.7 10 6 mol L 1. Limits of detection (LOD) and quantification (LOQ) were found to be 9.9 10 9 mol L 1 and 3.3 10 8 mol L 1, respectively. Furthermore, FLV oxidation at a glassy carbon electrode surface was used for its hydrodynamic monitoring by amperometric detection in a flow-injection system. The amperometric signal was linear with FLV concentration over the range 1.0 10 6 to 1.0 10 5 mol L 1, with an LOD of 2.4 10 7 mol L 1 and an LOQ of 8.0 10 7 mol L 1. A sample rate of 50 injections per hour was achieved. Both methods were validated and showed to be precise and accurate, being satisfactorily applied to the determination of FLV in a commercial pharmaceutical.|
|Versão do Editor:||http://www.tandfonline.com/doi/abs/10.1080/00032710802421889#.UooaQH9qyZQ|
|Aparece nas colecções:||ISEP – GRAQ – Artigos|
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|ART_MartaNeves_2008_GRAQ.pdf||356,64 kB||Adobe PDF||Ver/Abrir|
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