Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/2948
Título: Development of electrochemical methods for determination of tramadol - analytical application to pharmaceutical dosage forms
Autor: Garrido, E. Manuela
Garrido, Jorge
Borges, F.
Delerue-Matos, Cristina
Palavras-chave: Tramadol
Square-wave voltammetry
FIA
Electrochemical detection
Data: 2003
Editora: Elsevier
Relatório da Série N.º: Journal of Pharmaceutical and Biomedical Analysis; Vol. 32, Issue 4-5
Resumo: A square-wave voltammetric (SWV) method and a flow injection analysis system with amperometric detection were developed for the determination of tramadol hydrochloride. The SWV method enables the determination of tramadol over the concentration range of 15-75 µM with a detection limit of 2.2 µM. Tramadol could be determined in concentrations between 9 and 50 µM at a sampling rate of 90 h-1, with a detection limit of 1.7 µM using the flow injection system. The electrochemical methods developed were successfully applied to the determination of tramadol in pharmaceutical dosage forms, without any pre-treatment of the samples. Recovery trials were performed to assess the accuracy of the results; the values were between 97 and 102% for both methods.
Peer review: yes
URI: http://hdl.handle.net/10400.22/2948
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S0731708503001997#
Aparece nas colecções:ISEP – GRAQ – Artigos

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