A carregar...
Publicação
Static and hydrodynamic monitoring of citalopram based on its electro-oxidation behavior at a glassy-carbon surface
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 95.84 KB | Adobe PDF |
Orientador(es)
Resumo(s)
The electrooxidative behavior of citalopram (CTL) in aqueous media
was studied by cyclic voltammetry (CV) and square-wave voltammetry (SWV) at
a glassy-carbon electrode. The electrochemical behaviour of CTL involves two electrons
and two protons in the irreversible and diffusion controlled oxidation of the
tertiary amine group. The maximum analytical signal was obtained in a phosphate
buffer (pH ¼ 8.2). For analytical purposes, an SWV method and a flow-injection
analysis (FIA) system with amperometric detection were developed. The optimised
SWV method showed a linear range between 1.10 10 5–1.20 10 4 molL 1, with
a limit of detection (LOD) of 9.5 10 6 molL 1. Using the FIA method, a linear
range between 2.00 10 6–9.00 10 5 molL 1 and an LODof 1.9 10 6 molL 1
were obtained. The validation of both methods revealed good performance characteristics
confirming applicability for the quantification of CTL in several pharmaceutical
products.
Descrição
Palavras-chave
Amperometric detection Citalopram Flow-injection analysis Pharmaceutical analysis Square-wave voltammetry
Contexto Educativo
Citação
Editora
Taylor & Francis