Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/2935
Título: Voltammetric oxidation of drugs of abuse III. Heroin and metabolites
Autor: Garrido, Jorge
Delerue-Matos, Cristina
Borges, F.
Macedo, Tice R. A.
Oliveira-Brett, A. M.
Palavras-chave: Heroin
Drugs of abuse
Data: 2004
Editora: WILEY-VCH Verlag
Relatório da Série N.º: Electroanalysis; Vol. 16, Issue 18
Resumo: The oxidative behavior of heroin in aqueous solution is reported. In order to identify its oxidation peaks, several metabolites, 6-monoacetylmorphine, 3-monoacetylmorphine and norheroin, were synthesized and their electrochemical behavior studied using differential pulse voltammetry. The anodic waves observed for heroin correspond to the oxidation of the tertiary amine group and its follow-up product (secondary amine), and to the oxidation of the phenolic group obtained from hydrolysis, at alkaline pHs, of the 3-acetyl group. The results enabled a new oxidative mechanism for heroin to be proposed in which a secondary amine, norheroin, and an aldehyde are obtained. The voltammetric behavior of 6-monoacetylmorphine and morphine was found to be similar demonstrating that the presence of an acetyl substituent on the 6-hydroxy group does not have a relevant influence on the peak potential of the wave resulting from oxidation of the 3-phenolic group.
Peer review: yes
URI: http://hdl.handle.net/10400.22/2935
Versão do Editor: http://www.interscience.wiley.com/
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