Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/2930
Título: Voltammetric oxidation of drugs of abuse I. Morphine and metabolites
Autor: Garrido, Jorge
Delerue-Matos, Cristina
Borges, F.
Macedo, Tice R. A.
Oliveira-Brett, A. M.
Palavras-chave: Morphine
Pseudomorphine
Morphine N-oxide
Normorphine
Dihydromorphine
2-(N,NDimethylaminomethyl) morphine
Oxidation
Voltammetry
Drugs of abuse
Data: 2004
Editora: WILEY-VCH Verlag
Relatório da Série N.º: Electroanalysis; Vol. 16, Issue 7
Resumo: A detailed study of the electrochemical oxidative behavior of morphine in aqueous solution is reported. Through the synthesis of several metabolites and derivatives, pseudomorphine, morphine N-oxide, normorphine, dihydromorphine and 2-(N,N-dimethylaminomethyl)morphine, and their voltammetric study it was possible to identify the oxidation peaks for morphine. The anodic waves are related with the oxidation of phenolic and tertiary amine groups. It is also possible to verify that a poorly defined peak observable during morphine oxidation is not a consequence of further oxidation of pseudomorphine but due to formation of a dimer during phenolic group oxidation. The results obtained and especially those regarding the formation of a new polymer based on a C O coupling could be useful for clarifying the discoloration phenomenon occurring during storage of morphine solutions as well as leading to a better understanding of its oxidative metabolic pathways.
Peer review: yes
URI: http://hdl.handle.net/10400.22/2930
Versão do Editor: http://www.interscience.wiley.com/
Aparece nas colecções:ISEP – GRAQ – Artigos

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