Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/2897
Título: New insights into the oxidation pathways of apomorphine
Autor: Garrido, Jorge
Delerue-Matos, Cristina
Borges, Fernanda
Macedo, Tice R. A.
Oliveira-Brett, A. M.
Data: 2002
Editora: The Royal Society of Chemistry
Relatório da Série N.º: Journal of the Chemical Society, Perkin Transactions 2; Issue 10
Resumo: A detailed study of the oxidative behaviour of apomorphine in aqueous media is reported. Resorting to the synthesis of apomorphine derivatives it was possible to identify all the anodic oxidation peaks of apomorphine, which are related to the oxidation of the catechol and tertiary amine groups. These findings were revealed to be important since they could lead to a better understanding of the biological interactions of apomorphine and gain insight into its metabolic pathways. During the voltammetric studies, it was also found that apomorphine forms a complex with borate through the catechol group leading to an increase of its oxidation potential. This property could be very useful with regard to the stabilization of apomorphine solutions since it could drastically reduce its autoxidation.
Peer review: yes
URI: http://hdl.handle.net/10400.22/2897
Versão do Editor: http://pubs.rsc.org/en/Content/ArticleLanding/2002/P2/b204605a#!divAbstract
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