Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.22/1720
Título: Antimicrobial and cytotoxic assessment of marine cyanobacteria - synechocystis and synechococcus
Autor: Martins, Rosário
Ramos, Miguel
Herfindal, Lars
Sousa, José
Skærven, Kaja
Vasconcelos, Vítor
Palavras-chave: Marine cyanobacteria
Synechococcus
Antibiotic
Synechocystis
Data: 2008
Editora: Marine Drugs
Resumo: Aqueous extracts and organic solvent extracts of isolated marine cyanobacteria strains were tested for antimicrobial activity against a fungus, Gram-positive and Gram-negative bacteria and for cytotoxic activity against primary rat hepatocytes and HL-60 cells. Antimicrobial activity was based on the agar diffusion assay. Cytotoxic activity was measured by apoptotic cell death scored by cell surface evaluation and nuclear morphology. A high percentage of apoptotic cells were observed for HL-60 cells when treated with cyanobacterial organic extracts. Slight apoptotic effects were observed in primary rat hepatocytes when exposed to aqueous cyanobacterial extracts. Nine cyanobacteria strains were found to have antibiotic activity against two Gram-positive bacteria, Clavibacter michiganensis subsp. insidiosum and Cellulomonas uda. No inhibitory effects were found against the fungus Candida albicans and Gram-negative bacteria. Marine Synechocystis and Synechococcus extracts induce apoptosis in eukaryotic cells and cause inhibition of Gram-positive bacteria. The different activity in different extracts suggests different compounds with different polarities.
Peer review: yes
URI: http://hdl.handle.net/10400.22/1720
ISSN: 1660-3397
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